Antidiabetic Activity of Musa Sapientum Fruit Peel Extract on Streptozotocin Induced Diabetic Rats. S.sathiya Narayana Murthy

Musa sapientum have been used to treat numerous diseases for thousands of years in various parts of the world. The study was designed to evaluate the antidiabetic properties of this fruit peel by measuring the serum blood glucose level, HbA1c and the plasma insulin level. Thirty six male albino wistar rats were divided into six groups which received different treatments. The first group as control ,second and third groups served aspositive and negative control were treated with saline respectively,rats in the third group were received glibenclaimade. The fourth and fifth group was treated with Acetone extract of Musa sapientum fruit peel (MSPE) 200 and 400 mg/kg respectively. The sixth group was treated with normal rats with MSPE 800mg/kg. After 45 days of treatment, the plant extract significantly reduced the fasting blood glucose and the concentration of HbA1c in diabetic rats. The plasma insulin in diabetic rats was also significantly increased after treated with MSPE extract. These results suggest that the acetone extract of MSPE possess antidiabetic activity by improving the insulin secretion, with consequent decrease in the level of blood glucose and HbA1c.Histological section of the pancreas also proves its anti diabetic effect.